Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease.
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease.
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DOI：
10.1016/j.stemcr.2021.01.019
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发表时间：
2021-04-13
影响因子：
5.9
通讯作者：
Webb AE
中科院分区：
文献类型：
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作者：
Babcock KR;Page JS;Fallon JR;Webb AE
与阿尔茨海默病(AD)相关的认知缺陷严重影响了数百万受影响个人的日常生活。阿尔茨海默病患者进行性记忆障碍与海马体退变有关。海马齿状回是哺乳动物成年神经发生的场所，对学习和记忆功能至关重要。最近在人类身上的证据表明，海马神经发生可能持续整个生命，但随着年龄的增长而下降，并在AD时显著受损。我们对神经发生如何支持健康成年人的学习和记忆的理解才刚刚开始。神经发生减少在多大程度上导致了衰老和阿尔茨海默病的认知能力下降，目前仍知之甚少。然而，对阿尔茨海默病和其他神经退行性疾病啮齿动物模型的研究提出了靶向神经再生可能改善阿尔茨海默病认知功能障碍的可能性。在这里，我们回顾了最近的进展，了解如何影响成人神经发生在老龄化和AD的背景下。
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the millions of affected individuals. Progressive memory impairment in AD patients is associated with degeneration of the hippocampus. The dentate gyrus of the hippocampus, a region critical for learning and memory functions, is a site of adult neurogenesis in mammals. Recent evidence in humans indicates that hippocampal neurogenesis likely persists throughout life, but declines with age and is strikingly impaired in AD. Our understanding of how neurogenesis supports learning and memory in healthy adults is only beginning to emerge. The extent to which decreased neurogenesis contributes to cognitive decline in aging and AD remains poorly understood. However, studies in rodent models of AD and other neurodegenerative diseases raise the possibility that targeting neurogenesis may ameliorate cognitive dysfunction in AD. Here, we review recent progress in understanding how adult neurogenesis is impacted in the context of aging and AD.