Reduced frontal cortex efficiency is associated with lower white matter integrity in aging.
Reduced frontal cortex efficiency is associated with lower white matter integrity in aging.
复制标题
额叶皮层效率降低与衰老过程中白质完整性降低有关。
DOI：
10.1093/cercor/bht212
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Gold,BrianT
中科院分区：
文献类型：
--
作者：
Zhu,Zude;Johnson,NathanF;Kim,Chobok;Gold,BrianT
认知任务执行过程中额叶皮层激活增加在衰老中很常见，但仍然知之甚少。在这里，我们探讨了多种任务的执行条件下，与年龄相关的额叶脑激活模式及其与白色物质（WM）的微观结构的关系。年轻组（N= 28）和老年组（N= 33）的参与者完成了任务切换范式，而功能性磁共振成像（fMRI）进行，并休息，而扩散张量成像进行。从功能磁共振成像分析的结果表明，年龄相关的增加额叶脑激活的条件下，表现较差的老年组（非开关和开关条件），并在行为表现等同的对比（老年组非开关条件与年轻组开关条件）。在老年组中，在所有任务条件下，较高的额叶激活与较差的行为表现相关。在右额叶皮层的2个区域中，血氧水平依赖（BOLD）幅度与连接这些结构与其他任务相关的额顶叶和纹状体区域的脑束中的WM完整性呈负相关。我们的研究结果将年龄相关的额叶皮层功能效率下降与衰老中较低的WM完整性联系起来。
Increased frontal cortex activation during cognitive task performance is common in aging but remains poorly understood. Here we explored patterns of age-related frontal brain activations under multiple task performance conditions and their relationship to white matter (WM) microstructure. Groups of younger (N= 28) and older (N= 33) participants completed a task-switching paradigm while functional magnetic resonance imaging (fMRI) was performed, and rested while diffusion tensor imaging was performed. Results from fMRI analyses indicated age-related increases in frontal brain activations under conditions of poorer performance in the older group (the nonswitch and switch conditions) and for a contrast in which behavioral performance was equated (older group nonswitch condition vs. younger group switch condition). Within the older adult group, higher frontal activation was associated with poorer behavioral performance under all task conditions. In 2 regions in right frontal cortex, blood oxygen level–dependent (BOLD) magnitudes were negatively correlated with WM integrity in tracts connecting these structures with other task-relevant frontoparietal and striatal regions. Our results link age-related declines in the efficiency of frontal cortex functioning with lower WM integrity in aging.