INSULIN REGULATES THE 35-KDA IGF BINDING-PROTEIN IN PATIENTS WITH DIABETES-MELLITUS
INSULIN REGULATES THE 35-KDA IGF BINDING-PROTEIN IN PATIENTS WITH DIABETES-MELLITUS
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DOI：
10.1007/bf03350189
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发表时间：
1988-09-01
影响因子：
5.4
通讯作者：
HALL, K
中科院分区：
文献类型：
--
作者：
BRISMAR, K;GUTNIAK, M;HALL, K
本文用放射免疫法测定了56例门诊糖尿病患者血清低分子胰岛素样生长因子结合蛋白（IGFBP）的含量。在胰岛素依赖型糖尿病（IDDM）中发现35 kDa IGFBP的平均水平高三倍，112 ± 1.5kDa。13 ng/ml，而年龄匹配的对照组为37 . ±. 2ng/ml，而非胰岛素依赖型糖尿病（NIDDM）的平均水平为16 ± 1.2ng/ml。2 ng/ml。在住院的IDDM患者中，空腹血糖与35 kDaIGFBP水平之间存在显著的相关性（r = 0.91，p < 0.01），而在NIDDM患者中未发现。在胰岛素输注过程中，35 kDa IGFBP水平下降，半衰期为60-120 min。即使在稳态B-葡萄糖达到4.7 mmol/l后，IGFBP仍持续下降。总之，胰岛素依赖型糖尿病患者35 kDa IGFBP水平升高可归因于胰岛素缺乏，并可能反映靶细胞IGFs生物利用度降低。
The serum levels of the low molecular form of insulin-like growth factor binding protein (IGFBP) was determined in 56 outpatients with diabetes mellitus by a radioimmunoassay developed for amniotic 35 kDa IGFBP. The mean level of 35 kDa IGFBP was found to be threefold higher in insulin dependent diabetes mellitus (IDDM), 112 .+-. 13 ng/ml, than in age matched controls, 37 .+-. 2 ng/ml, while the mean level in non-insulin dependent diabetes mellitus (NIDDM), 16 .+-. 2 ng/ml, was decreased. In hospitalized IDDM patients there was a significant correlation (r = 0.91, p < 0.01) between fasting blood-glucose and 35 kDa IGFBP levels, not found in NIDDM patients. During insulin infusion the 35 kDa IGFBP levels declined with a half-life of 60-120 min. The decline in IGFBP continued even after the establishment of steady state B-glucose at 4.7 mmol/l. In conclusion, the elevated 35 kDa IGFBP levels in IDDM can be attributed to insulin deficiency and may reflect a reduced bioavailability of the IGFs at the target cells.