Pulmonary lymphangioleiomyomatosis: A case report with immunohistochemical details and DNA analysis
Pulmonary lymphangioleiomyomatosis: A case report with immunohistochemical details and DNA analysis
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DOI：
10.1620/tjem.199.119
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发表时间：
2003-02-01
影响因子：
2.2
通讯作者：
Sawai, T
中科院分区：
文献类型：
--
作者：
Pan, LH;Ito, H;Sawai, T
一位47岁的女性表现为肺淋巴管平滑肌瘤病（PLAM），累及双侧肺和轻微的肺功能异常。计算机断层扫描显示双侧肺微囊肿形成。组织学上主要表现为小叶中心型肺气肿的梭形细胞增生。免疫组化结果显示，这些增殖的梭形细胞a-平滑肌肌动蛋白、desmin、vimentin、HMB45、雌激素受体和孕激素受体呈阳性，S-100、细胞角蛋白呈阴性。单链构象多态性（SSCP）和DNA分析显示结节性硬化症I和2无明显异常。(C) 2003年东北大学医学出版社。
A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emphysema were main findings. Immunohistochemically, these proliferating spindle shaped cells were positive for a-smooth muscle actin, desmin, vimentin, HMB45, estrogen receptor and progesterone receptor, but negative for S-100, cytokeratin. Single strand conformation polymorphism (SSCP) and DNA analysis for tuberous sclerosis I and 2 showed no significant abnormality. (C) 2003 Tohoku University Medical Press.