Epidermal interleukin‐8 and its receptor CXCR2 in drug‐induced toxic epidermal necrolysis
Epidermal interleukin‐8 and its receptor CXCR2 in drug‐induced toxic epidermal necrolysis
复制标题
表皮白细胞介素8及其受体CXCR2在药物引起的中毒性表皮坏死松解症中的作用
DOI：
10.1111/j.1365-2230.2007.02482.x
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发表时间：
2007
影响因子：
4.1
通讯作者：
G. Piérard
中科院分区：
文献类型：
--
作者：
P. Paquet;C. Ribbens;G. Piérard
背景：在药物诱导的中毒性表皮坏死松解症（TEN）中，表皮破坏与轻度至中度淋巴单核细胞浸润有关。 白细胞介素（IL）-8是一种角质形成细胞衍生的促炎细胞因子，可能参与了这一过程。IL-8受体CXCR 2也被证明在一些表皮疾病中过表达。
Background. In drug‐induced toxic epidermal necrolysis (TEN), the epidermal destruction is associated with a slight to moderate lymphomonocytic cell infiltrate. Interleukin (IL)‐8, which is a keratinocyte‐derived pro‐inflammatory cytokine, might be involved in this process. The IL‐8 receptor CXCR2 has also been shown to be overexpressed in some epidermal disorders.