TOPOGRAPHY AND NOCICEPTIVE RECEPTIVE-FIELDS OF CLIMBING FIBERS PROJECTING TO THE CEREBELLAR ANTERIOR LOBE IN THE CAT
TOPOGRAPHY AND NOCICEPTIVE RECEPTIVE-FIELDS OF CLIMBING FIBERS PROJECTING TO THE CEREBELLAR ANTERIOR LOBE IN THE CAT
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DOI：
10.1113/jphysiol.1991.sp018750
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发表时间：
1991-09-01
影响因子：
5.5
通讯作者：
SCHOUENBORG, J
中科院分区：
文献类型：
--
作者：
EKEROT, CF;GARWICZ, M;SCHOUENBORG, J
1. 在戊巴比妥麻醉的猫上，绘制了投射到小脑前叶C3区前肢区的225条爬行纤维的皮肤感受野，并在浦肯野细胞上记录了爬行纤维的反应. 在内侧C3区，感受野覆盖前肢近端和/或外侧部分的攀爬纤维投射到最内侧。 攀爬纤维与感受野位于更内侧的前肢预测连续更横向。 在外侧C3区发现的感受野的顺序大致相反，在内侧C3区。 感受野仅限于手指的攀爬纤维优先投射到前肢区的尾侧部分，而感受野覆盖前臂近端和腹侧区域的攀爬纤维则投射到更多的吻侧部分。 前肢的表现是不均匀的。 接受领域与重点放在手指或沿着外侧的前臂占主导地位。4. 感受野的近端边界位于关节附近。 诱发最大反应的区域通常位于感受野的偏心位置。 根据感受野的空间分布特征，可将其分为8类，并将其进一步分为亚类。 在不同的猫中发现了类似的感受野亚类。 这一分类进一步支持了89攀援纤维的定量分析结果。 用标准伤害性刺激绘制这些攀缘纤维的感受野. 终止于矢状条（宽，100-300 μ m;长，> 1 mm）内的攀援纤维具有属于同一亚类的感受野。 这些微区之间的感受野通常会发生突变。 大多数类别的感受野被发现在内侧和外侧部分的C3区。 然而，只在C3区的内侧部分发现了在掌骨、手腕或前臂的腹侧上具有焦点的感受野。 此外，仅在C3区的外侧部分发现了限制在上臂和肩部外侧的感受野类别。 在讨论中，有人提出，攀登纤维投射到每个微区进行信息从脊髓多感受性反射弧作用于一个单一的肌肉或一组协同肌肉。 这进一步表明，每个微区控制相应的运动神经元池（S）的活动，通过前插入核和红核的途径。
1. The cutaneous receptive fields of 225 climbing fibres projecting to the forelimb area of the C3 zone in the cerebellar anterior lobe were mapped in the pentobarbitone-anaesthetized cat. Responses in climbing fibres were recorded as complex spikes in Purkinje cells.2. A detailed topographical organization of the nociceptive climbing fibre input to the C3 zone was found. In the medial C3 zone climbing fibres with receptive fields covering proximal and/or lateral parts of the forelimb projected most medially. Climbing fibres with receptive fields located more medially on the forelimb projected successively more laterally. The sequence of receptive fields found in the lateral C3 zone was roughly the reverse of that in the medial C3 zone. Climbing fibres with receptive fields restricted to the digits projected preferentially to the caudal part of the forelimb area, whereas those with receptive fields covering both proximal and ventral areas of the forearm projected to more rostral parts.3. The representation of the forelimb was uneven. Receptive fields with a focus on the digits or along the lateral side of the forearm dominated.4. The proximal borders of the receptive fields were located close to joints. The area from which maximal responses were evoked was usually located eccentrically within the receptive field. Based on spatial characteristics the receptive fields could be divided into eight classes, which in turn were tentatively divided into subclasses. Similar subclasses of receptive fields were found in different cats. This classification was further supported by the results of a quantitative analysis of eighty-nine climbing fibres. The receptive fields of these climbing fibres were mapped with standardized noxious stimulation.5. Climbing fibres terminating within sagittal strips (width, 100-300-mu-m; length, > 1 mm) had receptive fields which belonged to the same subclass. There were commonly abrupt changes in receptive fields between such microzones. Most classes of receptive fields were found in both the medial and the lateral parts of the C3 zone. However, receptive fields with a focus on the ventral side of either the metacarpals, the wrist or the forearm were found only in the medial part of the C3 zone. Furthermore, the class of receptive fields restricted to the lateral side of the upper arm and shoulder was only found in the lateral part of the C3 zone.6. In the discussion, it is proposed that climbing fibres projecting to each microzone carry information from spinal multireceptive reflex arcs acting on a single muscle or a group of synergistic muscles. It is further suggested that each microzone controls the activity of the corresponding motoneurone pool(s) via pathways through the anterior interposed nucleus and the red nucleus.