Signaling by committee: Receptor clusters determine pathways of cellular activation
Signaling by committee: Receptor clusters determine pathways of cellular activation
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DOI：
10.1021/cb700214x
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发表时间：
2007-10-01
影响因子：
4
通讯作者：
Cairo, Christopher W.
中科院分区：
文献类型：
--
作者：
Cairo, Christopher W.
受体聚集是细胞表面受体的一种常见信号机制。外源配体，如抗体或合成类似物，可用于人工诱导聚集。使用已定义的合成配体的新研究表明，这些簇的空间组织减弱了一条途径中的信号，但对另一条途径没有影响。
Receptor clustering is a common signaling mechanism for cell surface receptors. Exogenous ligands such as antibodies or synthetic analogues can be used to artificially induce clustering. New studies using defined synthetic ligands suggest that the spatial organization of these clusters attenuates signaling in one pathway but has no effect in another.