Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
复制标题
DOI：
10.1016/j.jvc.2012.01.009
复制
发表时间：
2012-03-01
影响因子：
1.2
通讯作者：
Elliott, Jonathan
中科院分区：
文献类型：
--
作者：
Hezzell, Melanie J.;Boswood, Adrian;Elliott, Jonathan
目的：确定二尖瓣粘液瘤性疾病(MMVD)犬心脏死亡的超声心动图测量是否有更大的变化。动物：客户拥有的不同严重程度的MMVD犬(n=242)来自第一意见私人诊所。只有在研究期间死亡的犬(n=102)被纳入统计分析。方法：前瞻性队列研究比较发生心源性死亡的犬和经历非心源性死亡的犬的超声心动图变量变化率。大约每6个月重复测量一次，并构建重复测量的线性模型，以估计每个变量随时间的变化率。结果：两组死亡患者的左心室(LV)舒张末内径(LVEDDN)随时间增加。心源性死亡组左心室收缩末期内径(LVESDN)、左心室舒张末内径/左心室舒张期游离壁厚度(LVEDD/LVFWd)、E峰速度、E-A峰速度比和左房/主动脉根部内径比值均随时间延长而增加，而非心源性死亡组无明显变化。在心源性死亡组中，MR血流速度随时间而降低，而在非心源性死亡组中则无变化。在两组死亡率中，三尖瓣返流速度随时间增加。结论：每隔6-12个月进行一次连续超声心动图检查有助于识别进展性MMVD的犬心脏死亡风险增加。(C)2012爱思唯尔B.V.保留所有权利。
Objectives: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality.Animals: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs which died during the study period (n = 102) were included in statistical analyses.Methods: Prospective cohort study comparing the rate of change of echocardiographic variables between dogs that experienced cardiac mortality and those that experienced non-cardiac mortality. Measurements were repeated approximately every 6 months and repeated measures linear models were constructed to estimate the rate of change of each variable over time.Results: Left ventricular (LV) end-diastolic diameter, normalized for body weight (LVEDDN) increased over time in both mortality groups. LV end-systolic diameter, normalized for body weight (LVESDN), LV end-diastolic diameter to LV free wall thickness in diastole (LVEDD/LVFWd) ratio, E wave velocity, E- to A-wave velocity ratio and left atrial to aortic root diameter ratio all increased over time in the cardiac mortality group, but did not change in the non-cardiac mortality group. MR velocity decreased over time in the cardiac mortality group but did not change in the non-cardiac mortality group. Tricuspid regurgitation jet velocity increased over time in both mortality groups. A wave velocity and fractional shortening did not change over time in either mortality group.Conclusions: Serial echocardiographic examination every 6-12 months is useful to identify dogs with progressive MMVD that are at increased risk of cardiac mortality. (C) 2012 Elsevier B.V. All rights reserved.