Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia.
Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia.
复制标题
硫酸软骨素可减轻福尔马林引起的持续性触觉异常性疼痛。
DOI：
10.1016/j.jphs.2016.07.009
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Koichi Tan-No
中科院分区：
文献类型：
--
作者：
Wataru Nemoto;Kotaro Yamada;Yoshiki Ogata;Osamu Nakagawasai;Katsuhito Onodera;Hidetomo Sakurai;Koichi Tan-No
我们研究了硫酸软骨素（CS），一种用于治疗骨关节炎和关节疼痛的化合物，对福尔马林诱导的小鼠触觉异常性疼痛的影响。重复经口施用CS（300 mg/kg，b.i.d.）从福尔马林注射后第10天起显著改善福尔马林诱导的触觉异常性疼痛。在第14天，脊髓p38 MAPK的磷酸化和随后的c-Fos免疫反应性背侧腰神经元的增加被CS的重复给药衰减。这些结果表明，CS减弱福尔马林诱导的触觉异常性疼痛通过抑制p38 MAPK磷酸化和随后上调c-Fos表达在背侧腰髓。
We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS. These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.