CALCIUM-CHANNEL BLOCKERS AND BEHAVIORAL SENSITIZATION
CALCIUM-CHANNEL BLOCKERS AND BEHAVIORAL SENSITIZATION
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DOI：
10.1016/0024-3205(91)90029-b
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
CALDER, LD
中科院分区：
文献类型：
--
作者：
KARLER, R;TURKANIS, SA;CALDER, LD
安非他明诱导的刻板行为敏化以前被证明是由两个独立的现象，诱导和表达，这两者都涉及兴奋性氨基酸（EAA）。 在本实验中，钙通道阻滞剂（CCB），硝苯地平，地尔硫卓和维拉帕米，被证明可以阻止这两种现象，这些结果是类似的DNQX，非N-甲基-D-天冬氨酸受体的EAA的拮抗剂早期报道。 CCB与DNQX一样，只影响由致敏反应引起的刻板反应的百分比，而不影响可归因于安非他明急性效应的反应的定量部分。 结果支持以前的结论，敏化反应包括两个定量成分，其中只有一个涉及EAA。 CCB表现出的拮抗作用表明行为敏感化涉及Ca++和L型钙通道。
Behavioral sensitization to amphetamine-induced stereotypy was previously shown to consist of two separable phenomena, induction and expression, both of which involve the excitatory amino acids (EAA). In the present experiments, the calcium channel blockers (CCB), nifedipine, diltiazem and verapamil, were shown to block both phenomena; these results are similar to those reported earlier for DNQX, an antagonist of the non-N-methyl-D-aspartate receptors for the EAA. The CCB, like DNQX, affect only that percentage of the stereotypic response which results from the sensitization reaction, without affecting the quantitative portion of the response attributable to the acute effect of amphetamine. The results support previous conclusions that the sensitization response consists of two quantitative components, only one of which involves the EAA. The antagonism exhibited by the CCB suggests that behavioral sensitization involves Ca++ and L-type calcium channels.