"Fantastic thinking" in pathologically proven Pick disease.
"Fantastic thinking" in pathologically proven Pick disease.
复制标题
病理证实的皮克病的“奇幻思维”。
DOI：
10.1097/wnn.0b013e3181df3007
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Mendez,MarioF
中科院分区：
文献类型：
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作者：
Kremen,SarahA;Solis,OrestesE;Shapira,JillS;Vinters,HarryV;Mendez,MarioF
错误信念的报告可能是行为变异性额颞叶痴呆（bvFTD）的一个独特特征，但这些经历的性质尚不清楚。目的报告一例经病理证实的匹克病，患者表现为反复出现的明显幻想。方法我们描述了一名53岁女性的临床、神经影像学和神经病理学表现，她表现出幻想，符合bvFTD的临床共识标准。结果在她的课程早期，她报告了与不同演员的互动，与他们有激烈的恋情，以及其他相关的幻想。当面对她的错误信念时，她承认这些关系是想象出来的。尸检显示匹克病在额叶和颞叶皮层以及海马区具有τ免疫反应性匹克体。结论幻想思维或生动体验的想象力可能是bvFTD不同于妄想和虚构的一种表现，可能是先前报道的bvFTD妄想和虚构的来源。
BackgroundReports of false beliefs may be a unique feature of behavioral variant frontotemporal dementia (bvFTD) but the nature of these experiences is unclear.ObjectiveTo report a case of pathologically verified Pick disease in a patient presenting with prominent and recurrent fantasies.MethodsWe describe the clinical, neuroradiologic, and neuropathologic findings of a 53-year-old woman presenting with fantasies and meeting Clinical Consensus Criteria for bvFTD.ResultsEarly in her course, she reported interactions with different actors, having torrid affairs with them, and other related fantasies. When confronted with her false beliefs, she admitted that these relationships were imaginary. Autopsy revealed Pick disease with τ-immunoreactive Pick bodies in the frontal and temporal cortices, and in the hippocampi.ConclusionsFantastic thinking, or vividly experienced imagination, may be a manifestation of bvFTD that is distinct from delusions and confabulations and could be the source of previously reported delusions and confabulations in bvFTD.