CONCERTED SIGNALING BY RETINAL GANGLION-CELLS
CONCERTED SIGNALING BY RETINAL GANGLION-CELLS
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DOI：
10.1126/science.270.5239.1207
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发表时间：
1995-11-17
期刊：
影响因子：
56.9
通讯作者：
BAYLOR, DA
中科院分区：
文献类型：
--
作者：
MEISTER, M;LAGNADO, L;BAYLOR, DA
为了分析控制眼睛和大脑之间交流的规则，我们记录了一只完整的火蜥蜴视网膜的视觉反应。用微电极阵列对许多视网膜神经节细胞的平行观察显示，附近的神经元经常同步放电，峰延迟不到10毫秒。这种同步尖峰的频率超过了共享视觉刺激的预期相关性，高达20倍。同步放电在各种视觉刺激下持续存在，并占所记录的动作电位的大部分。对感受野的分析表明，协调的棘波编码的信息不是由单个细胞携带的；它们可能代表着视觉的多神经元编码中的符号。
To analyze the rules that govern communication between eye and brain, visual responses were recorded from an intact salamander retina. Parallel observation of many retinal ganglion cells with a microelectrode array showed that nearby neurons often fired synchronously, with spike delays of less than 10 milliseconds. The frequency of such synchronous spikes exceeded the correlation expected from a shared visual stimulus up to 20-fold. Synchronous firing persisted under a variety of visual stimuli and accounted for the majority of action potentials recorded. Analysis of receptive fields showed that concerted spikes encoded information not carried by individual cells; they may represent symbols in a multineuronal code for vision.