Simultaneous measurements of lactate turnover rate and umbilical lactate uptake in the fetal lamb.
Simultaneous measurements of lactate turnover rate and umbilical lactate uptake in the fetal lamb.
复制标题
同时测量胎羔的乳酸周转率和脐带乳酸摄取量。
DOI：
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发表时间：
1982
影响因子：
15.9
通讯作者：
Frederick C. Battaglia
中科院分区：
文献类型：
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作者：
J. W. Sparks;William W. Hay;Duane Bonds;Giacomo Meschia;Frederick C. Battaglia
乳酸是胚胎羔羊在宫内发育的主要外源营养物质。我们的研究是(A)量化胎儿乳酸的净摄入量，(B)量化胎盘乳酸的净产生和代谢，以及(C)用放射性示踪剂同时测量比较胎儿乳酸的净摄入量和胎儿乳酸的使用量。14只妊娠绵羊在母羊股动脉和子宫静脉、胎儿主动脉和脐静脉留置导管。通过同时将菲克原理应用于子宫和脐循环，胎盘葡萄糖消耗和胎盘乳酸产生迅速，平均为39.8+/-5.1和11.8+/-0.7毫克·分-1。脐血乳酸净摄取量平均为1.95+/-0.16 mg-1.kg.min-1。在L-[14C(U)]乳酸盐输注过程中，胎儿乳酸代谢较快，平均为6.5+/-0.8 mg·kg-1·min-1，解剖胎儿体内乳酸利用率为5.9+/-0.7 mg·kg-1·min-1。在输注示踪剂葡萄糖期间，葡萄糖和非葡萄糖底物产生的内源性胎儿乳酸平均分别为3.0和1.5 mg·kg-1·min-1。目前的研究已定量的条件下，充分的氧气，稳定的条件下，胎盘的快速代谢和乳酸的产生，胎儿乳酸的净消耗量，以及快速内源性胎儿乳酸从葡萄糖和非葡萄糖底物产生。
Lactic acid represents a major exogenous nutrient for the developing fetal lamb in utero. Our study was undertaken (a) to quantitate the net consumption of lactate by the fetus, (b) to quantitate the net lactate production and metabolism by the placenta, and (c) to compare the net fetal lactate consumption with fetal lactate use, measured simultaneously with radioactive tracers. 14 pregnant sheep were prepared with catheters in the maternal femoral artery and uterine vein and in the fetal aorta and umbilical vein. By simultaneous application of the Fick principle to the uterine and umbilical circulations, placental glucose consumption and placental lactate production were rapid, averaging 39.8 +/- 5.1 and 11.8 +/- 0.7 mg.min-1. Net lactate umbilical uptake averaged 1.95 +/- 0.16 mg-1.kg.min-1. During infusion of L-[14C(U)]lactate, fetal lactate turnover was much more rapid, averaging 6.5 +/- 0.8 mg.kg-1.min-1, and lactate utilization within the anatomic fetus was 5.9 +/- 0.7 mg.kg-1.min-1. During infusion of tracer glucose, endogenous fetal lactate production from glucose and nonglucose substrates averaged 3.0 and 1.5 mg.kg-1.min-1, respectively. The present studies have quantitated under well oxygenated, steady-state conditions, the rapid placental metabolism and production of lactate, the net fetal consumption of lactate, and the rapid endogenous fetal lactate production from glucose and nonglucose substrates.
影响因子：
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作者：
HAY, WW;SPARKS, JW;MESCHIA, G
通讯作者：
MESCHIA, G