Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Ageing Study (FAMAS)
Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Ageing Study (FAMAS)
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DOI：
10.1111/j.1365-2265.2008.03463.x
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发表时间：
2009-08-01
影响因子：
3.2
通讯作者：
Wittert, Gary A.
中科院分区：
文献类型：
--
作者：
Atlantis, Evan;Martin, Sean A.;Wittert, Gary A.
血浆雄激素水平与男性的健康状况呈负相关，与年龄相关的雄激素水平下降可能是由年龄本身以外的因素引起的。本研究旨在确定人口统计学、身体和生活方式因素对男性年龄相关雄激素状态的影响。设计一项对居住在澳大利亚阿德莱德西北地区的具有区域代表性的男性人群的观察性调查。研究样本包括1195名年龄在35-81岁之间的男性，应答率为45中心点1%。测量血浆总睾酮（TT）水平，测量生物可利用的睾酮（BT）、SHBG、胰岛素样肽3（INSL 3）和促性腺激素，沿着广泛的人口统计学、身体和生活方式因素，包括身体组成、肌肉力量和慢性疾病的生物标志物，身体活动，结果低TT主要与高腹部脂肪和甘油三酯以及低肌肉力量有关，而不是衰老本身。低BT与年龄增加相关，其次是高全身脂肪百分比。未婚男性和吸烟者的BT和TT水平较高。SHBG水平随着年龄的增长而增加，但也与胰岛素和甘油三酯呈负相关。Leydig细胞特异性因子INSL 3是与TT和BT相关的最强生物标志物。结论与低雄激素状态相关的因素不同，包括高体脂百分比、低肌肉力量和代谢综合征的生物标志物。减少暴露于对雄激素状态产生不利影响的因素可能会改善老年男性的总体健康状况，其机制尚未确定。
P>ObjectivePlasma androgen levels are inversely associated with health in men, the age-related decline of which may result from factors other than ageing per se. This study aimed to determine the effects of demographic, physical and lifestyle factors on age-related androgen status in men.DesignAn observational survey of a regionally representative male population residing in the North West regions of Adelaide, Australia.ParticipantsStudy sample includes 1195 men aged 35-81 years with a response rate of 45 center dot 1%.MeasurementsPlasma levels of total testosterone (TT), bioavailable testosterone (BT), SHBG, insulin-like peptide 3 (INSL3), and gonadotrophins were measured along with an extensive list of demographic, physical and lifestyle factors including body composition, muscle strength and biomarkers of chronic diseases, physical activity, nutrition and smoking behaviour.ResultsLow TT was mostly associated with high abdominal fat and triglycerides and low muscle strength rather than ageing per se. Low BT was associated with increased age followed by high whole body fat percentage. BT and TT levels were higher in unmarried men and smokers. SHBG levels increased with age, but were also inversely associated with insulin and triglycerides. The Leydig cell specific factor INSL3 was the strongest biomarker associated with both TT and BT.ConclusionsFactors associated with low androgen status variably include high body fat percentage, low muscle strength and biomarkers of the metabolic syndrome. Reducing exposure to factors that adversely affect androgen status may improve the general health of ageing men by mechanisms yet to be defined.