EPIDERMAL LIPIDS, BARRIER FUNCTION, AND DESQUAMATION
EPIDERMAL LIPIDS, BARRIER FUNCTION, AND DESQUAMATION
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DOI：
10.1038/jid.1983.12
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发表时间：
1983-01-01
影响因子：
6.5
通讯作者：
ELIAS, PM
中科院分区：
文献类型：
--
作者：
ELIAS, PM
基于最近的形态学、组织化学和生化数据，我们提出了角质层的异质双室模型，认为细胞间脂质在角质层屏障功能和脱屑的调节中起着特殊作用。本文综述了支持该模型的证据和基于该模型的几种预测。
Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.