Some observations on the in vitro cytotoxicity of chrysotile prepared by the wet dispersion process.
Some observations on the in vitro cytotoxicity of chrysotile prepared by the wet dispersion process.
复制标题
湿法分散法制备温石棉体外细胞毒性的一些观察。
DOI：
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发表时间：
1983
影响因子：
10.4
通讯作者：
A. Wright
中科院分区：
文献类型：
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作者：
I. P. Gormley;R. Bolton;G. M. Brown;J. M. Davis;A. Wright
对在湿分散工艺处理过程中和处理之后采集的温石棉样品进行了体外细胞毒性效应测试，并将测试结果与UICC温石棉A样品和从标准温石棉纺织纱线中制备的粉尘进行了比较。从使用P388 D1、V79-4和A549细胞的三种不同体外测定系统获得结果。仍然含有在湿分散过程中使用的润湿剂的样品在这些测定中的任何一个中都没有显示出活性。然而，其他样品都具有活性，通过研磨最终产品和对工厂空气取样获得的粉尘始终证明比标准温石棉对照物具有更大的细胞毒性。来自平行体内研究的初步结果表明，这些样品在大鼠中产生间皮瘤方面也更活跃。
Samples of the chrysotile taken during and after treatment by the wet dispersion process have been tested for their cytotoxic effect in vitro and the results compared with both a UICC chrysotile A sample and a dust prepared from a standard chrysotile textile yarn. Results were obtained from three different in vitro assay systems utilizing P388D1, V79-4 and A549 cells. A sample which still contained the wetting agent used in the wet dispersion process failed to show activity in any of these assays. The other samples, however, were all active with those dusts obtained by milling the final product and by sampling the air of the factory consistently proving significantly more cytotoxic than the standard chrysotile controls. Preliminary results from a parallel in vivo study suggest that these samples are also more active in producing mesotheliomas in rats.