Synthesis of Chiral N-Heterocyclic Carbene Ligands with Rigid Backbones and Application to the Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
Synthesis of Chiral N-Heterocyclic Carbene Ligands with Rigid Backbones and Application to the Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
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DOI：
10.1021/ol200149s
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发表时间：
2011-04-01
期刊：
影响因子：
5.2
通讯作者：
Murakami, Masahiro
中科院分区：
文献类型：
--
作者：
Liu, Lantao;Ishida, Naoki;Murakami, Masahiro
开发了具有2，2 '-双喹啉基C-2对称骨架的手性N-杂环卡宾（NHC）配体。在钯催化的酰胺分子内α-芳基化反应中，该配体表现出良好的对映选择性，得到了3，3-二取代羟吲哚。
Chiral N-heterocyclic carbene (NHC) ligands having a 2,2'-bisquinoline-based C-2 symmetric skeleton were developed. The ligands exhibited good enantioselectivity in palladium-catalyzed intramolecular alpha-arylation of amides to give 3,3-disubsituted oxindoles.