Chlamydia cell biology and pathogenesis.
Chlamydia cell biology and pathogenesis.
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DOI：
10.1038/nrmicro.2016.30
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Engel J
中科院分区：
文献类型：
--
作者：
Elwell C;Mirrashidi K;Engel J
衣原体属是导致人类疾病的重要原因，目前还没有有效的疫苗。这些专性细胞内病原体在专门的膜区室中复制，并使用大量的分泌效应器在宿主的敌对细胞内环境中生存。在这篇综述中，我们总结了解码衣原体属之间相互作用的进展。衣原体蛋白质组学和遗传学的最新技术进步使之成为可能。该领域现在准备破译衣原体之间密切相互作用的分子机制。及其宿主，这将为这些医学上重要的病原体的研究开辟许多令人兴奋的途径。
Chlamydia spp. are important causes of human disease for which no effective vaccine exists. These obligate intracellular pathogens replicate in a specialized membrane compartment and use a large arsenal of secreted effectors to survive in the hostile intracellular environment of the host. In this Review, we summarize the progress in decoding the interactions between Chlamydia spp. and their hosts that has been made possible by recent technological advances in chlamydial proteomics and genetics. The field is now poised to decipher the molecular mechanisms that underlie the intimate interactions between Chlamydia spp. and their hosts, which will open up many exciting avenues of research for these medically important pathogens.