Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury.
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Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited this therapeutic approach to continuous stimulation applied to restricted spinal cord locations. Here, we developed novel stimulation protocols that reproduce the natural dynamics of motoneuron activation during locomotion. For this, we computed the spatiotemporal activation pattern of muscle synergies during locomotion in healthy rats. Computer simulations identified optimal electrode locations to target each synergy through the recruitment of proprioceptive feedback circuits. This framework steered the design of spatially selective spinal implants and real–time control software that modulate extensor versus flexor synergies with precise temporal resolution. Spatiotemporal neuromodulation therapies improved gait quality, weight–bearing capacities, endurance and skilled locomotion in multiple rodent models of spinal cord injury. These new concepts are directly translatable to strategies to improve motor control in humans.
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影响因子：
4
作者：
Holinski BJ;Everaert DG;Mushahwar VK;Stein RB
通讯作者：
Stein RB
影响因子：
5.3
作者：
Capogrosso, Marco;Wenger, Nikolaus;Micera, Silvestro
通讯作者：
Micera, Silvestro
影响因子：
3
作者：
Gerasimenko, Yury P.;Lavrov, Igor A.;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie
影响因子：
3.5
作者：
Afshar, Pedram;Khambhati, Ankit;Denison, Tim
通讯作者：
Denison, Tim
影响因子：
--
作者：
Edgerton, V. Reggie;Courtine, Gregoire;Roy, Roland R.
通讯作者：
Roy, Roland R.