Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats
Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats
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DOI：
10.1152/ajpregu.1999.277.3.r786
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发表时间：
1999-09-01
影响因子：
2.8
通讯作者：
De Groat, WC
中科院分区：
文献类型：
--
作者：
Cheng, CL;Liu, JC;De Groat, WC
在麻醉的正常猫以及麻醉和清醒的慢性脊髓损伤（SCI）猫中，研究了辣椒素（10-80 mg/kg sc）对膀胱反射活动的影响。在正常猫中，辣椒素引起等容膀胱收缩频率的短暂增加，并降低诱导排尿的容量阈值，但不抑制膀胱收缩的幅度或对膀胱神经的反射放电。在麻醉SCI猫，辣椒素抑制反射膀胱活动和膀胱神经放电。在清醒的SCI猫，辣椒素最初降低的体积阈值诱导排尿，然而，延迟3-6小时后，体积阈值增加，膀胱内排尿压力下降。这种效果持续4-12天。结论：辣椒素敏感性C纤维膀胱传入神经在正常猫中不参与反射性排尿的起始，但在慢性SCI猫中触发自动排尿起重要作用。结果与临床资料一致，表明C纤维膀胱传入有助于神经源性膀胱功能障碍患者的膀胱过度活动和尿失禁。
The effect of capsaicin (10-80 mg/kg sc) on reflex activity of the urinary bladder was examined in anesthetized normal as well as anesthetized and awake chronic spinal cord-injured (SCI) cats. In normal cats, capsaicin elicited a transient increase in the frequency of isovolumetric bladder contractions and reduced the volume threshold for inducing micturition, but did not depress the amplitude of bladder contractions or the reflex firing on bladder nerves. In anesthetized SCI cats, capsaicin depressed reflex bladder activity and firing on bladder nerves. In awake SCI cats, capsaicin initially decreased the volume threshold for inducing micturition; however, after a delay of 3-6 h the volume threshold increased and intravesical voiding pressure decreased. This effect persisted for 4-12 days. It is concluded that capsaicin-sensitive C fiber bladder afferents are not involved in initiating reflex micturition in normal cats, but play an essential role in triggering automatic micturition in chronic SCI cats. The results are consistent with the clinical data indicating that C fiber bladder afferents contribute to bladder hyperactivity and incontinence in patients with neurogenic bladder dysfunction.