Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood
Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood
复制标题
血小板纤溶酶原激活剂抑制剂：人血液中两种不同的内皮细胞型纤溶酶原激活剂抑制剂池
DOI：
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发表时间：
1986
影响因子：
6.7
通讯作者：
B. G. Jansen
中科院分区：
文献类型：
--
作者：
E. Sprengers;J. Akkerman;B. G. Jansen
本文介绍了一种检测人血小板纤溶酶原激活物抑制物的方法。用该方法测得健康人群平均血小板数为6.8×10−8IU(SD=3.0×10−8；n=2 0)。我们对来自血小板的PA-抑制物进行了表征，并根据其免疫学和功能特性将其鉴定为内皮细胞型纤溶酶原激活物抑制物。除了血浆池中的纤溶酶原激活物抑制物具有非常高的周转率外，血小板还构成了循环中第二个同等数量级的纤溶酶原激活物抑制物池。两种不同的纤溶酶原激活物抑制物可能具有不同的生理功能。
Summary An assay for plasminogen activator inhibitor in human platelets is described. With this assay we find an average value of 6.8 × 10−8 IU/platelet (S.D. = 3.0 × 10−8; n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibitor might have a different physiologic function.
DOI：
10.1016/s0021-9258(17)42691-3
发表时间：
1984-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. V. van Mourik;D. Lawrence;D. Loskutoff
通讯作者：
J. V. van Mourik;D. Lawrence;D. Loskutoff
DOI：
10.1073/pnas.80.10.2956
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
LOSKUTOFF, DJ;VANMOURIK, JA;LAWRENCE, D
通讯作者：
LAWRENCE, D