PERIPHERAL NEUROPATHY IN DIABETIC MONKEYS
PERIPHERAL NEUROPATHY IN DIABETIC MONKEYS
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DOI：
10.2337/diabetes.38.11.1365
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发表时间：
1989-11-01
期刊：
影响因子：
7.7
通讯作者：
HANSEN, BC
中科院分区：
文献类型：
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作者：
CORNBLATH, DR;HILLMAN, MA;HANSEN, BC
周围神经病变是人类糖尿病的重要并发症和发病率的来源。适当的实验模型可能有助于了解其发病机制和制定治疗策略。我们试图确定是否有糖尿病的肥胖成年猴发生周围神经病变，以及它是否与高血糖症的发作有关。我们研究了13只成年雄性恒河猴的运动神经（腓神经、正中神经和尺神经）和感觉神经（正中神经和尺神经）的神经传导，其中4只明显患有糖尿病，9只非糖尿病（平均年龄21 ± 10岁）。2和16 .+-。2年，分别为NS;平均空腹血糖14.5 θ。3.4和4.4 .+-。0.6 mM，P = .001）。糖尿病动物运动传导速度明显降低，F波潜伏期延长。运动诱发的振幅没有差异。在糖尿病猴中，运动纤维中的神经传导时间增加，这可以在高血糖症发作后2年内发现。这些异常与在人类中观察到的异常相似，并建议将这些动物作为人类糖尿病神经病变的灵长类动物模型进行进一步研究。
Peripheral neuropathy is a significant complication of human diabetes and a source of morbidity. Appropriate experimental models may aid in understanding its pathogenesis and in developing therapeutic strategies. We sought to determine whether spotaneously diabetic obese adult monkeys developed peripheral neuropathy and whether it ocurred early or late in relation to the onset of hyperglycemia. We studied nerve conduction in both motor (peroneal, median, and ulnar) and sensory (median and ulnar) nerves in 13 adults male rhesus monkeys, 4 overtly diabetic and 9 nondiabetic (mean age 21 .+-. 2 and 16 .+-. 2 yr, respectvely, NS; mean fasting plasma glucose 14.5 .THETA. 3.4 and 4.4 .+-. 0.6 mM, P = .001). The diabetic animals had signifcantly reduced motor conduction velocities and and prolonged F-wave latencies. Motor-evoked amplitudes did not differ. In the diabetic monkeys, nerve conduction time were increased in motor fibers, which could be identified as early as 2 yr after the onset of hyperglycemia. These abnormalities are similar to those seen in humans and suggests further study of these animals as a primate model of human diabetic neuropathy.