Prostate cancer progression and mortality: a review of diet and lifestyle factors.
Prostate cancer progression and mortality: a review of diet and lifestyle factors.
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DOI：
10.1007/s00345-016-1914-3
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发表时间：
2017-06
影响因子：
3.4
通讯作者：
Kenfield SA
中科院分区：
文献类型：
--
作者：
Peisch SF;Van Blarigan EL;Chan JM;Stampfer MJ;Kenfield SA
回顾和总结有关饮食和生活方式因素与前列腺癌进展的作用的证据，特别关注诊断后的习惯以及随后疾病复发、进展或死亡的风险。考虑到前列腺癌的异质性和大多数诊断的长期生存期，我们的目标是总结和描述临床相关前列腺癌的可改变的危险因素。我们尽可能关注诊断后习惯和前列腺癌进展的流行病学研究，定义为复发（例如 PSA 风险、二次治疗）、转移或死亡。在数据有限的情况下，我们还描述了诊断时前列腺癌侵袭性的危险因素和指标的证据。多种饮食和生活方式因素似乎会影响前列腺癌的进展。一些普遍推荐的生活方式因素，例如不吸烟、保持健康的体重和定期进行剧烈的体育锻炼，似乎也会影响前列腺癌的进展。一些饮食因素，如番茄酱/番茄红素、十字花科蔬菜、健康的植物脂肪来源和咖啡，也可能有助于降低前列腺癌进展的风险。饮食和生活方式因素，特别是锻炼和戒烟，可能会降低前列腺癌进展和死亡的风险。这些有希望的发现值得进一步研究，因为它们的总体影响可能很大。
To review and summarize evidence on the role of diet and lifestyle factors and prostate cancer progression, with a specific focus on habits after diagnosis and the risk of subsequent disease recurrence, progression, or death. Given the well-documented heterogeneity of prostate cancer and the long survivorship of the majority of diagnoses, our goal was to summarize and describe modifiable risk factors for clinically relevant prostate cancer. We focused where possible on epidemiologic studies of post-diagnostic habits and prostate cancer progression, defined as recurrence (e.g., PSA risk, secondary treatment), metastasis, or death. Where data were limited, we also describe evidence on risk factors and indicators of prostate cancer aggressiveness at diagnosis. A variety of dietary and lifestyle factors appear to affect prostate cancer progression. Several generally widely recommended lifestyle factors such as not smoking, maintaining a healthy body weight, and regular vigorous physical exercise also appear to affect prostate cancer progression. Several dietary factors, such as tomato sauce/lycopene, cruciferous vegetables, healthy sources of vegetable fats, and coffee, may also have a role in reducing risk of prostate cancer progression. Diet and lifestyle factors, in particular exercise and smoking cessation, may reduce the risk of prostate cancer progression and death. These promising findings warrant further investigation, as their overall impact might be large.