Magnetic nanoparticle imaging using harmonic signals
Magnetic nanoparticle imaging using harmonic signals
复制标题
使用谐波信号的磁性纳米粒子成像
DOI：
10.1109/tmag.2012.2198440
复制
发表时间：
2012
影响因子：
2.1
通讯作者：
N. B. Othman et al.
中科院分区：
文献类型：
--
作者：
川人祥二;見崎龍;閨宏司;徐〓雄;今井快多;安富啓太;香川景一郎;N. B. Othman et al.
我们开发了一个磁纳米粒子（MNP）成像系统，利用磁纳米粒子的非线性磁化曲线的基础上的谐波信号。通过对谐波信号的测量，可以显著降低激励场的干扰，从而提高检测灵敏度。首先，我们从MNP获得信号场的等高线图，从中我们估计它们的位置。我们可以检测到100 μg位于拾取线圈下方30 mm处的MNP，信噪比为4。接下来，我们使用称为奇异值分解（SVD）的数学技术来分析等高线图，以提高估计位置的空间分辨率。使用SVD方法，我们将场映射转换为MNP分布。我们可以清楚地区分两个MNP样品之间的距离为x =20 mm，位于Δz=20 mm。这种简单的检测系统将是有用的医学应用，如前哨淋巴结检测。
We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. By measuring the harmonic signals, the interference of the excitation field can be significantly decreased, so the detection sensitivity can be improved. First, we obtained a contour map of the signal field from the MNPs, from which we estimated their positions. We could detect 100 μg of MNPs located atz=30 mm below the pickup coil with a signal-to-noise ratio of 4. Next, we analyzed the contour map using a mathematical technique called singular value decomposition (SVD) in order to improve the spatial resolution of the estimated position. Using the SVD method, we converted the field map to the MNP distribution. We could clearly distinguish two MNP samples separated byx=20 mm and located at Δz=20 mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.