The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.

The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.
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DOI:
10.1016/j.cytogfr.2020.10.008
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发表时间:
2021-03
影响因子:
13
通讯作者:
Caputi M
Caputi M
中科院分区:
医学2区
文献类型:
--
作者:
Paz S;Ritchie A;Mauer C;Caputi M

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丝氨酸/精氨酸剪接因子1 (SRSF1)是一种在大多数组织中大量表达的RNA结合蛋白。SRSF1具有多种功能,通过调控转录、加工、核孔输出和新生RNA转录物翻译的主要步骤,在基因表达中发挥多种作用。这篇综述的目的是强调该蛋白功能的最新发现,并描述其在免疫系统发育、功能和调节中的作用。
Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The aim of this review is to highlight recent findings in the functions of this protein and to describe its role in immune system development, functions and regulation.
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