Type I interferons: key players in normal skin and select cutaneous malignancies.
Type I interferons: key players in normal skin and select cutaneous malignancies.
复制标题
I型干扰素：正常皮肤中的关键参与者和选择皮肤恶性肿瘤。
DOI：
10.1155/2014/847545
复制
发表时间：
2014
影响因子：
1.5
通讯作者：
Yusuf N
中科院分区：
文献类型：
--
作者：
Ismail A;Yusuf N
干扰素（IFN）是一个天然存在的糖蛋白家族，已知其抗病毒活性和影响正常和转化细胞类型行为的能力。I型干扰素包括IFN-α和IFN-β。目前，IFN-α具有许多批准的抗肿瘤应用，包括恶性黑色素瘤，其中IFN-α已显示出增加无复发生存期。此外，IFN-α已成功用于皮肤鳞状细胞癌（SCC）和基底细胞癌（BCC）的病灶内治疗。尽管有这些有希望的临床结果;但是，在皮肤恶性肿瘤（如SCC、BCC和黑色素瘤）中，关于IFN-α/β在细胞和分子水平上的精确抗肿瘤作用的知识很少。本文综述了目前的知识，在何种程度上I型干扰素影响增殖，凋亡，血管生成和免疫功能在正常皮肤，皮肤SCC，BCC，黑色素瘤。
Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN-α and IFN-β. Currently, IFN-α has numerous approved antitumor applications, including malignant melanoma, in which IFN-α has been shown to increase relapse free survival. Moreover, IFN-α has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-α/β at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma.