Manganese-Catalyzed C−H Annulation of Ketimines with Allenes: Stereoselective Synthesis of 1-Aminoindanes
Manganese-Catalyzed C−H Annulation of Ketimines with Allenes: Stereoselective Synthesis of 1-Aminoindanes
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DOI：
10.1002/adsc.201800465
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发表时间：
2018-06
影响因子：
5.4
通讯作者：
Chong Lei;Lijie Peng;K. Ding
中科院分区：
文献类型：
--
作者：
Chong Lei;Lijie Peng;K. Ding
本文报道了一种锰催化的酮亚胺与多取代酯活化的联烯的C-H环化反应，合成了带有两个邻位全取代碳立体中心和一个环外双键的1-氨基茚满。该反应具有高的非对映选择性、高的E/Z选择性、100%的原子经济性、宽的底物范围和良好的官能团耐受性。
A manganese‐catalyzed C−H annulation of ketimines with poly‐substituted ester‐activated allenes toward the synthesis of 1‐aminoindanes bearing two vicinal all‐substituted carbon stereocenters and an exocyclic double bond was developed. The reaction features high diastereoselectivity, highE/Zselectivity, 100% atom‐economy, broad substrate scope and good functional group tolerance.