Epidermal cell-derived thymocyte activating factor (ETAF) is a potent T-cell chemoattractant.
Epidermal cell-derived thymocyte activating factor (ETAF) is a potent T-cell chemoattractant.
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表皮细胞源性胸腺细胞激活因子 (ETAF) 是一种有效的 T 细胞趋化剂。
DOI：
10.1111/1523-1747.ep12277126
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Hunninghake,GW
中科院分区：
文献类型：
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作者：
Sauder,DN;Monick,MM;Hunninghake,GW
表皮，特别是表皮细胞因子，已显示调节许多炎症和细胞免疫应答。在这项研究中，我们已经证明，部分纯化的表皮细胞因子，表皮胸腺细胞激活因子（ETAF），由角质形成细胞释放的多肽，是一种有效的T细胞化学引诱物。与其增强凝集素刺激的胸腺细胞增殖的能力相比，ETAF作为T细胞化学引诱物更活跃。本研究结果进一步支持了局部表皮因子在免疫反应中的作用。这一发现可能与以皮肤中T细胞浸润为特征的病理状态特别相关，例如皮肤T细胞淋巴瘤。
The epidermis, in particular epidermal cytokines, have been shown to modulate a number of inflammatory and cellular immune responses. In this study we have demonstrated that the partially purified epidermal cytokine, epidermal thymocyte activating factor (ETAF), a polypeptide released by keratinocytes, is a potent T-cell chemoattractant. Compared to its ability to augment lectin-stimulated thymocyte proliferation, ETAF is much more active as a T-cell chemoattractant. The results of this study give further support to the role of local epidermal factors in immune reactivity. This finding may have particular relevance to pathologic states characterized by T-cell infiltration in the skin, such as cutaneous T-cell lymphoma.