Translation regulation via nascent polypeptide-mediated ribosome stalling
Translation regulation via nascent polypeptide-mediated ribosome stalling
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DOI：
10.1016/j.sbi.2016.01.008
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发表时间：
2016-04-01
影响因子：
6.8
通讯作者：
Beckmann, Roland
中科院分区：
文献类型：
--
作者：
Wilson, Daniel N.;Arenz, Stefan;Beckmann, Roland
当新生的多肽链被合成时，它穿过大核糖体亚基内的隧道。新生多肽链和核糖体通道之间的相互作用可以调节翻译速率并诱导翻译停滞以调节基因表达。在本文中，我们重点介绍了新生多肽链如何单独或与辅因子配合，与核糖体通道的成分相互作用，通过失活核糖体肽基转移酶中心并诱导核糖体停滞来调节翻译的最新结构见解。
As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Interaction between the nascent polypeptide chain and the ribosomal tunnel can modulate the translation rate and induce translational stalling to regulate gene expression. In this article, we highlight recent structural insights into how the nascent polypeptide chain, either alone or in cooperation with co-factors, can interact with components of the ribosomal tunnel to regulate translation via inactivating the peptidyltransferase center of the ribosome and inducing ribosome stalling.