Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1
Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β1
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DOI：
10.3324/haematol.2010.039743
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发表时间：
2011-09-01
期刊：
影响因子：
--
通讯作者：
Boyiadzis, Michael
中科院分区：
文献类型：
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作者：
Szczepanski, Miroslaw J.;Szajnik, Marta;Boyiadzis, Michael
背景：与正常对照相比，急性髓系白血病患者的自然杀伤细胞毒性降低。存在于患者血清中的肿瘤源性微泡对免疫细胞产生有害影响，并可能影响肿瘤进展。设计与方法研究新诊断急性髓系白血病患者的微囊泡蛋白水平、分子特征及自然杀伤细胞活性的抑制。结果患者血清中微囊泡含量高于对照组(P
BackgroundNatural killer cell cytotoxicity is decreased in patients with acute myeloid leukemia in comparison to that in normal controls. Tumor-derived microvesicles present in patients' sera exert detrimental effects on immune cells and may influence tumor progression.Design and MethodsWe investigated the microvesicle protein level, molecular profile and suppression of natural killer cell activity in patients with newly diagnosed acute myeloid leukemia.ResultsThe patients' sera contained higher levels of microvesicles compared to the levels in controls (P