INVIVO STUDIES OF CARTILAGE REGENERATION AFTER DAMAGE INDUCED BY CATABOLIN INTERLEUKIN-1
INVIVO STUDIES OF CARTILAGE REGENERATION AFTER DAMAGE INDUCED BY CATABOLIN INTERLEUKIN-1
复制标题
DOI：
10.1136/ard.50.2.75
复制
发表时间：
1991-02-01
影响因子：
27.4
通讯作者：
DINGLE, JT
中科院分区：
文献类型：
--
作者：
THOMAS, DPP;KING, B;DINGLE, JT
兔膝关节细胞因子引起的损伤的短暂发作的反应进行了描述。 在三次关节内注射分解代谢素/白细胞介素-1后，所有关节软骨显示出蛋白聚糖（糖胺聚糖）的立即广泛损失，其在三至四周内逐渐被替换。 糖胺聚糖的生物合成（通过（SO 4）-S-35摄取测量）最初受到抑制，但在一周时，与正常侧相比，其速率几乎翻了一番。 这种增加的合成活性在整个实验期间（28天）得到进一步维持，尽管速率逐渐下降。 甲苯胺蓝的组织学软骨异染反映了糖胺聚糖的变化。 没有发现关节软骨胶原网络的紊乱，因此认为，在关节炎治疗过程中，固有软骨细胞必须继续能够进行再生基质修复，抗关节炎药物应首先筛选干扰该过程。
The response of the rabbit knee joint to a brief episode of cytokine induced damage is described. After three intra-articular injections of catabolin/interleukin-1 all joint cartilages showed an immediate extensive loss of proteoglycan (glycosaminoglycan), which was gradually replaced over three to four weeks. Glycosaminoglycan biosynthesis (measured by (SO4)-S-35 uptake) was initially depressed, but at one week had almost doubled its rate as compared with the normal side. This increased synthetic activity was further maintained throughout the duration of the experiment (28 days), though the rate gradually fell. Histological cartilage metachromasia to toluidine blue mirrored the glycosaminoglycan changes. No disturbance of the articular cartilage collagen network was found.It is considered, therefore, that during treatment for arthritis the indigenous chondrocyte must continue to be capable of carrying out regenerative matrix repair and that antiarthritic agents should first be screened for interference with that process.