Effects of smoking and abstention from smoking on fibrinogen synthesis in humans.
Effects of smoking and abstention from smoking on fibrinogen synthesis in humans.
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DOI：
10.1042/cs1000459
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发表时间：
2001-04
期刊：
影响因子：
6
通讯作者：
K. Hunter;P. Garlick;I. Broom;S. Anderson;M. Mcnurlan
中科院分区：
文献类型：
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作者：
K. Hunter;P. Garlick;I. Broom;S. Anderson;M. Mcnurlan
吸烟和高纤维蛋白原血症都是心血管疾病发生的重要危险因素。本文介绍了两项旨在确定吸烟者血浆纤维蛋白原浓度升高的代谢机制的研究。与非吸烟者相比，慢性吸烟者具有显著升高的纤维蛋白原合成（ASR）的绝对速率（22.7 +/-1.3mg/kg/天对16.0 +/-1.3mg/kg/天;平均值+/- S.E.M.，血浆纤维蛋白原水平与纤维蛋白原合成呈显著正相关（r = 0.65，P = 0.04）。与纤维蛋白原不同，吸烟者的血浆白蛋白浓度低于非吸烟者（45 +/- 0.4 vs 47 +/- 0.7 g/l，P < 0.05），但两组之间的白蛋白合成率没有差异。戒烟两周后，慢性吸烟者血浆纤维蛋白原浓度迅速显著下降（从3.06 +/- 0.11 g/l到2.49 +/- 0.14 g/l，P < 0.001），并且ASR显著降低（降低33%，从24.1 +/- 1.7降至16.1 +/- 1.0 mg/kg/天，P < 0.001）。这些研究表明，在产生与吸烟相关的高纤维蛋白原血症中，合成增加的主要作用。此外，戒烟仅2周就可引起肝脏纤维蛋白原合成速率的显著降低，同时血浆纤维蛋白原浓度也随之降低。
Cigarette smoking and hyperfibrinogenaemia are both significant risk factors for the development of cardiovascular disease. Two studies are described here which aimed to establish the metabolic mechanism responsible for the raised plasma fibrinogen concentration observed in smokers. Chronic smokers had a significantly elevated absolute rate of fibrinogen synthesis (ASR) compared with non-smokers (22.7 +/- 1.3 mg/kg per day versus 16.0 +/- 1.3 mg/kg per day; means +/- S.E.M., P < 0.01), with plasma levels of fibrinogen significantly correlated with fibrinogen synthesis (r = 0.65, P = 0.04). Unlike fibrinogen, plasma albumin concentrations were lower in smokers than in non-smokers (45 +/- 0.4 versus 47 +/- 0.7 g/l, P < 0.05), but there was no difference in rates of albumin synthesis between the two groups. Two weeks cessation from smoking by previously chronic smokers was associated with a rapid and marked fall in plasma fibrinogen concentration (from 3.06 +/- 0.11 g/l to 2.49 +/- 0.14 g/l, P < 0.001), and a significant reduction in ASR (a 33% reduction, from 24.1 +/- 1.7 to 16.1 +/- 1.0 mg/kg per day, P < 0.001). These studies suggest a primary role for increased synthesis in producing the hyperfibrinogenaemia associated with smoking. Moreover, abstention from smoking for a period of only 2 weeks induces a significant decrease in the rate of fibrinogen synthesis by the liver, with a concomitant reduction in the plasma fibrinogen concentration.