Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils
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DOI：
10.1128/aac.42.9.2206
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发表时间：
1998-09-01
影响因子：
4.9
通讯作者：
Lehrer, RI
中科院分区：
文献类型：
--
作者：
Turner, J;Cho, Y;Lehrer, RI
人中性粒细胞含有两种结构不同的抗菌肽，P-折叠防御素（HNP-1至HNP-4）和α-螺旋肽LL-37，我们使用径向扩散测定法和改进的国家临床实验室标准委员会（National Committee for Clinical Laboratory Standards）型肉汤微量稀释测定法来比较LL-37、HNP-1和保护蛋白（PG-1）的抗微生物性质，尽管通常不如PC-1有效，LL-37显示出相当大的活性（MIC，
Human neutrophils contain two structurally distinct types of antimicrobial peptides, P-sheet defensins (HNP-1 to HNP-4) and the alpha-helical peptide LL-37, We used radial diffusion assays and an improved National Committee for Clinical Laboratory Standards-type broth microdilution assay to compare the antimicrobial properties of LL-37, HNP-1, and protegrin (PG-1), Although generally less potent than PC-1, LL-37 showed considerable activity (MIC,