The distribution, excretion and metabolism of hydroxyurea-C14.
The distribution, excretion and metabolism of hydroxyurea-C14.
复制标题
羟基脲-C14的分布、排泄和代谢。
DOI：
--
复制
发表时间：
1965
影响因子：
3.5
通讯作者：
J. D. Davidson
中科院分区：
文献类型：
--
作者：
R. Adamson;S. L. Ague;S. Hess;J. D. Davidson
The fate of radioactive hydroxyurea (HU-C14) has been studied in mice and rats following single parenteral and oral doses.
One-half hour after parenteral administration in mice, radioactivity was present in all tissues and organs examined but was predominant in the kidneys and bladder with contents.
Following parenteral dosage at two levels, three-fourths of the radioactivity was recovered in the urine with trace amounts in the feces after 24 hours. No difference in excretion pattern was noted following oral administration.
In rats, similar results were obtained following parenteral administration.
Urine samples were analyzed by high-voltage paper electrophoresis and an adaptation of the Fearon carbamido reaction to the Technicon AutoAnalyzer. Urea-C14 and C14O2 were identified as metabolites of HU-C14 in mouse urine.
In vitro experiments determined that mouse liver and kidney minces were able to convert HU-C14 to urea-C14.
