Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells
Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells
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DOI：
10.1016/j.canlet.2005.02.047
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发表时间：
2006-02-20
期刊：
影响因子：
9.7
通讯作者：
Muramatsu, T
中科院分区：
文献类型：
--
作者：
Salama, RHM;Muramatsu, H;Muramatsu, T
Midkine 是一种肝素结合生长因子，由许多肿瘤细胞表达，有助于肿瘤细胞在体外和体内的生长。当肿瘤生长在大腿上方皮下时，Lewis肺癌细胞不显着表达MK，其自发性肺转移在中期因子基因缺陷的小鼠中明显小于野生型小鼠。 Midkine 强烈增强 Lewis 肺癌细胞的体外迁移。因此，中期因子也是增强肿瘤转移的宿主因子。恶性肿瘤的抗中期因子治疗可能作用于肿瘤和宿主产生的中期因子。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Midkine is a heparin-binding growth factor and is expressed by a number of tumor cells, contributing to their growth both in vitro and in vivo. Spontaneous lung metastasis of Lewis lung carcinoma cells, which did not significantly express MK, was significantly less extensive in mice deficient in the midkine gene than in wild-type mice, when the tumor was subcutaneously grown above the thigh. Midkine strongly enhanced migration of Lewis lung carcinoma cells in vitro. Therefore, midkine is also a host factor enhancing tumor metastasis. Anti-midkine therapy for malignancy may act on midkine produced by both the tumor and host. (c) 2005 Elsevier Ireland Ltd. All rights reserved.