Leptin levels are associated with multiple sclerosis risk
Leptin levels are associated with multiple sclerosis risk
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DOI：
10.1177/1352458520905033
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发表时间：
2020-02-07
影响因子：
5.8
通讯作者：
Sundstrom, Peter
中科院分区：
文献类型：
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作者：
Bistrom, Martin;Hultdin, Johan;Sundstrom, Peter
背景：生命早期的肥胖与罹患多发性硬化症 (MS) 的风险增加有关。瘦素和胰岛素都与肥胖相关，因此适合研究这种联系。 目的：确定瘦素和胰岛素是否是复发缓解型多发性硬化症 (RRMS) 的危险因素。 方法：在这项使用瑞典生物样本库血液样本的巢式病例对照研究中，我们比较了 649 名后来患上 RRMS 的个体和 649 名与生物样本库、性别、年龄和采样日期相匹配的对照者的瘦素和胰岛素浓度。仅包括从 40 岁以下个体中抽取的症状前样本。对 z 评分值进行条件逻辑回归，计算比值比 (OR) 和 95% 置信区间 (CI)。 结果：瘦素 z 评分增加 1 个单位与 20 岁以下个体（OR = 1.4，95% CI = 1.1-1.9）和所有男性（OR = 1.4，95% CI = 1.0-2.0）罹患 MS 的风险增加相关。相比之下，对于 30-39 岁的女性，在调整胰岛素水平时，随着瘦素水平升高，患 MS 的风险较低（OR = 0.74，95% CI = 0.54-1.0）。结论：我们表明，促炎脂肪因子瘦素是年轻人患 MS 的危险因素。
Background:Obesity early in life has been linked to increased risk of developing multiple sclerosis (MS). Leptin and insulin are both associated with obesity, making them suitable candidates for investigating this connection.Objective:To determine if leptin and insulin are risk factors for relapsing-remitting multiple sclerosis (RRMS).Methods:In this nested case-control study using blood samples from Swedish biobanks, we compared concentrations of leptin and insulin in 649 individuals who later developed RRMS with 649 controls matched for biobank, sex, age and date of sampling. Only pre-symptomatically drawn samples from individuals below the age of 40 years were included. Conditional logistic regression was performed on z-scored values to calculate odds ratios (ORs) with 95% confidence intervals (CIs).Results:A 1-unit leptin z-score increase was associated with increased risk of MS in individuals younger than 20 years (OR = 1.4, 95% CI = 1.1-1.9) and in all men (OR = 1.4, 95% CI = 1.0-2.0). In contrast, for women aged 30-39 years, there was a lower risk of MS with increased leptin levels (OR = 0.74, 95% CI = 0.54-1.0) when adjusting for insulin levels.Conclusion:We show that the pro-inflammatory adipokine leptin is a risk factor for MS among young individuals.