Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip
Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip
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DOI：
10.1007/s00264-004-0608-4
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发表时间：
2005-02-01
影响因子：
2.7
通讯作者：
Engel, A
中科院分区：
文献类型：
--
作者：
Berger, CE;Kröner, A;Engel, A
我们比较了18例快速破坏性骨关节病患者和20例缓慢进展性髋关节病患者血清交联型C末端多肽(ICTP)对I型胶原降解的影响。本病的诊断是通过临床检查和X线评价。所有患者均行全髋关节置换术。检测血清ICTP、骨特异性碱性磷酸酶、骨钙素和N末端前肽水平。快速破坏性骨关节病患者的血清ICTP平均水平高于缓慢进展性骨关节病患者[13.2(5.6)ng/m l(1.4)ng/m l(P=0.001)]，而其他各项指标在两组间均无显著差异。ICTP水平的升高与髋关节X线片评估的关节间隙宽度的减小显著相关(p=0.01)。我们的数据表明，快速破坏性髋关节病与血清ICTP水平升高有关，反映了I型胶原降解的增加。
We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.