Correlation among body height, intelligence, and brain gray matter volume in healthy children
Correlation among body height, intelligence, and brain gray matter volume in healthy children
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DOI：
10.1016/j.neuroimage.2011.08.092
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发表时间：
2012-01
期刊：
影响因子：
5.7
通讯作者：
Y. Taki;H. Hashizume;Y. Sassa;H. Takeuchi;M. Asano;K. Asano;Yuka Kotozaki;R. Nouchi;Kai Wu;H. Fukuda;R. Kawashima
中科院分区：
文献类型：
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作者：
Y. Taki;H. Hashizume;Y. Sassa;H. Takeuchi;M. Asano;K. Asano;Yuka Kotozaki;R. Nouchi;Kai Wu;H. Fukuda;R. Kawashima
儿童的身高和智力之间存在显著的正相关关系。此外，智力与儿童大脑中灰质的体积有关。在此基础上，利用160例5 - 18岁健康儿童的脑磁共振图像数据，应用基于体素的形态测量法分析了身高、全尺寸智商（IQ）和灰质体积之间的相关性。结果表明，身高与脑灰质体积呈显著正相关。此外，双侧前额叶皮质、颞顶叶和小脑等区域的灰质体积与身高呈显著正相关，在调整年龄、性别和社会经济地位后，这些区域的灰质体积也与全面智商（IQ）得分呈显著正相关。我们的研究结果表明，灰质和白质体积可能在健康儿童身高和智力之间的相关性中起中介作用。此外，灰质和白质体积、身高和智力之间的相关性至少可以部分地用胰岛素样生长因子-1和生长激素的作用来解释。考虑到环境因素，特别是营养对身高、智商和灰质体积的影响的重要性，目前的研究结果强调了儿童时期营养对身体和大脑健康成熟的重要性。
A significant positive correlation between height and intelligence has been demonstrated in children. Additionally, intelligence has been associated with the volume of gray matter in the brains of children. Based on these correlations, we analyzed the correlation among height, full-scale intelligence quotient (IQ) and gray matter volume applying voxel-based morphometry using data from the brain magnetic resonance images of 160 healthy children aged 5–18years of age. As a result, body height was significantly positively correlated with brain gray matter volume. Additionally, the regional gray matter volume of several regions such as the bilateral prefrontal cortices, temporoparietal region, and cerebellum was significantly positively correlated with body height and that the gray matter volume of several of these regions was also significantly positively correlated with full-scale intelligence quotient (IQ) scores after adjusting for age, sex, and socioeconomic status. Our results demonstrate that gray and white matter volume may mediate the correlation between body height and intelligence in healthy children. Additionally, the correlations among gray and white matter volume, height, and intelligence may be at least partially explained by the effect of insulin-like growth factor-1 and growth hormones. Given the importance of the effect of environmental factors, especially nutrition, on height, IQ, and gray matter volume, the present results stress the importance of nutrition during childhood for the healthy maturation of body and brain.