An Electric Field Model for Prediction of Somatosensory (S1) Cortical Field Potentials Induced by Ventral Posterior Lateral (VPL) Thalamic Microstimulation
An Electric Field Model for Prediction of Somatosensory (S1) Cortical Field Potentials Induced by Ventral Posterior Lateral (VPL) Thalamic Microstimulation
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DOI：
10.1109/tnsre.2011.2181417
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发表时间：
2012-03-01
影响因子：
4.9
通讯作者：
Francis, Joseph Thachil
中科院分区：
文献类型：
--
作者：
Choi, John Stephen;DiStasio, Marcello Michael;Francis, Joseph Thachil
微刺激（MiSt）在实验和临床上用于激活神经元的局部群体。然而，很难预测并随后控制神经对通过阵列中的多个电极同时注入电流的反应。这是由于细胞外介质中的神经元元件的未知位置由多个并联电流源的叠加激发。因此，我们提出了一个模型，该模型将一个大脑区域中刺激电极周围的3-D空间中的计算电场映射到下游区域中诱发的局部场电位（LFP）波动。我们的模型是训练与记录LFP波形在初级体感皮层（S1）产生的MiSt应用于多个电极配置在腹后外侧核（VPL）的安静清醒大鼠。然后，我们预测皮质反应MiSt在“新颖”的电极配置，结果表明，这种技术可以通过多电极阵列的空间优化的MiSt图案的设计。
Microstimulation (MiSt) is used experimentally and clinically to activate localized populations of neural elements. However, it is difficult to predict-and subsequently control-neural responses to simultaneous current injection through multiple electrodes in an array. This is due to the unknown locations of neuronal elements in the extracellular medium that are excited by the superposition of multiple parallel current sources. We, therefore, propose a model that maps the computed electric field in the 3-D space surrounding the stimulating electrodes in one brain region to the local field potential (LFP) fluctuations evoked in a downstream region. Our model is trained with the recorded LFP waveforms in the primary somatosensory cortex (S1) resulting from MiSt applied in multiple electrode configurations in the ventral posterolateral nucleus (VPL) of the quiet awake rat. We then predict the cortical responses to MiSt in "novel" electrode configurations, a result that suggests that this technique could aid in the design of spatially optimized MiSt patterns through a multielectrode array.