HUMAN H-Y - A MALE-SPECIFIC HISTOCOMPATIBILITY ANTIGEN DERIVED FROM THE SMCY PROTEIN
HUMAN H-Y - A MALE-SPECIFIC HISTOCOMPATIBILITY ANTIGEN DERIVED FROM THE SMCY PROTEIN
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DOI：
10.1126/science.7667640
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发表时间：
1995-09-15
期刊：
影响因子：
56.9
通讯作者：
ENGELHARD, VH
中科院分区：
文献类型：
--
作者：
WANG, W;MEADOWS, LR;ENGELHARD, VH
H-Y是一种移植抗原，即使供体和受体在人类的主要组织相容性位点HLA（人类白细胞抗原）位点匹配，也会导致女性受体对男性器官和骨髓移植产生排斥反应。然而，H-Y抗原的起源和功能一直困扰着研究人员40年。HLA-B7呈递的一种人H-Y抗原被鉴定为源自Y染色体上的进化保守蛋白SMCY的11个残基肽，该蛋白来自X染色体上的同源基因SMCX，在同一区域有两个氨基酸残基不同。确定H-Y可能有助于移植预后、产前诊断和受精策略。
H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus, However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome, The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.