Selectivity-enhanced glucose measurement in multicomponent aqueous solution by broadband dielectric spectroscopy
Selectivity-enhanced glucose measurement in multicomponent aqueous solution by broadband dielectric spectroscopy
复制标题
通过宽带介电谱选择性增强多组分水溶液中的葡萄糖测量
DOI：
10.1109/mwsym.2016.7540257
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
H. Koizumi
中科院分区：
文献类型：
--
作者：
Masahito Nakamura;T. Tajima;K. Ajito;H. Koizumi
我们证明了检测生理范围的葡萄糖在多组分水溶液中，通过多变量分析的宽带介电谱从500 MHz到50 GHz。为了提高对葡萄糖的选择性，我们对介电谱进行了光谱预处理，提取了葡萄糖和牛血清白蛋白（BSA）的特征值。利用不同浓度葡萄糖和BSA的回归模型，对两种组分生理范围内的溶液进行了分析。即使在各种浓度的BSA中，葡萄糖浓度的预测误差估计也小于73 mg/dL。这种技术很容易与微波血糖传感器或其他生物医学应用，基本上需要多组分分析。
We demonstrate the detection of physiological-range glucose in a multicomponent aqueous solution through multivariate analysis of broadband dielectric spectra from 500 MHz to 50 GHz. To enhance the selectivity to glucose, we applied spectral preprocessing on dielectric spectra to extract the feature values of glucose and bovine serum albumin (BSA). Using the regression models derived from different concentrations of glucose and BSA, the analysis was carried out on the solutions with the physiological range of both components. The prediction error of glucose concentration was estimated at less than 73 mg/dL even in various concentrations of BSA. This technique is easily implemented with a microwave blood glucose sensor or in other biomedical applications that essentially require multicomponent analysis.