Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice
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DOI：
10.7554/elife.18128
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发表时间：
2017-03-06
期刊：
影响因子：
7.7
通讯作者：
Stone, Jennifer S.
中科院分区：
文献类型：
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作者：
Bucks, Stephanie A.;Cox, Brandon C.;Stone, Jennifer S.
内耳中的前庭毛细胞编码头部运动并调节平衡感。在非哺乳动物脊椎动物的一生中，这些细胞经历了细胞死亡和更替(更替)。然而，没有确凿的证据表明这一过程发生在哺乳动物身上。我们使用命运图和其他方法证明了在正常情况下，椭圆形II型前庭毛细胞在成年小鼠身上发生了翻转。我们发现支持细胞吞噬I型和II型毛细胞。表达Plp1-Creer(T2)的支持细胞取代II型毛细胞。表达Plp1-Creer(T2)的支持细胞或表达Atoh1-Creer(TM)的II型毛细胞不能恢复I型毛细胞。毛细胞的破坏会导致支持细胞产生的II型毛细胞是正常情况下的6倍。这些发现扩大了我们对成人前庭器官感觉神经可塑性的理解，并进一步阐明了支持细胞在动态平衡和损伤后所起的作用。
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreER(T2)-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreER(T2)-expressing supporting cells or by Atoh1-CreER(TM)-expressing type II hair cells. Destruction of hair cells causes supporting cells to generate 6 times as many type II hair cells compared to normal conditions. These findings expand our understanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that supporting cells serve during homeostasis and after injury.