Exercise training and blood lipids in hyperlipidemic and normolipidemic adults: A meta-analysis of randomized, controlled trials
Exercise training and blood lipids in hyperlipidemic and normolipidemic adults: A meta-analysis of randomized, controlled trials
复制标题
DOI：
10.1038/sj.ejcn.1600784
复制
发表时间：
1999-07-01
影响因子：
4.7
通讯作者：
Hamdorf, PA
中科院分区：
文献类型：
--
作者：
Halbert, JA;Silagy, CA;Hamdorf, PA
目的：确定运动训练（有氧和阻力）在改善血脂方面的有效性，并确定在持续时间、强度和频率方面优化血脂的最有效训练方案。设计：通过系统检索Medline、Embase、科学引文索引（SCI）、已发表的综述和相关试验的参考文献来确定试验。纳入标准仅限于进行至少四周的有氧和阻力运动训练的随机对照试验，并涉及以下一项或多项测量：总胆固醇（TC），高密度脂蛋白（HDL-C），低密度脂蛋白（LDL-C）和甘油三酯（TG）。受试者：共纳入31项试验（1833名高脂血症和正常脂血症受试者）。结果：有氧运动训练导致TC、LDL-C和TG分别降低0.10 mmol/L （95% CI: 0.02, 0.18）、0.10 （95% CI: 0.02, 0.19）、0.08 mmol/L (95% CI: 0.02, 0.14)， HDL-C增加0.05 mmol/L (95% CI: 0.02, 0.08)，虽小但有统计学意义。有氧运动项目强度之间的比较产生了不一致的结果；但更频繁的运动似乎并没有比每周运动三次更能改善血脂状况。抗阻运动训练效果的证据尚无定论。结论：考虑到比较的显著异质性，在从本研究中得出确定的结论时需要谨慎。然而，研究结果似乎表明，有氧运动训练对以前久坐不动的成年人的血脂产生了微小但有利的改变。赞助：公共卫生研究和发展项目赠款，国家卫生和医学研究理事会，卫生、住房、地方政府和社区服务部，1995年。
Objective: To determine the effectiveness of exercise training (aerobic and resistance) in modifying blood lipids, and to determine the most effective training programme with regard to duration, intensity and frequency for optimizing the blood lipid profile.Design: Trials were identified by a systematic search of Medline, Embase, Science Citation Index (SCI), published reviews and the references of relevant trials. The inclusion criteria were limited to randomized, controlled trials of aerobic and resistance exercise training which were conducted over a minimum of four weeks and involved measurement of one or more of the following: total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) and triglycerides (TG).Subjects: A total of 31 trials (1833 hyperlipidemic and normolipidemic participants) were included.Results: Aerobic exercise training resulted in small but statistically significant decreases of 0.10 mmol/L (95% CI: 0.02, 0.18), 0.10 (95% CI: 0.02, 0.19), 0.08 mmol/L (95% CI: 0.02, 0.14), for TC, LDL-C, and TG, respectively, with an increase in HDL-C of 0.05 mmol/L (95% CI: 0.02, 0.08). Comparisons between the intensities of the aerobic exercise programmes produced inconsistent results; but more frequent exercise did not appear to result in greater improvements to the lipid profile than exercise three times per week. The evidence for the effect of resistance exercise training was inconclusive.Conclusions: Caution is required when drawing firm conclusions from this study given the significant heterogeneity with comparisons. However, the results appear to indicate that aerobic exercise training produced small but favourable modifications to blood lipids in previously sedentary adults.Sponsorship: public Health Research and Development Project Grant, National Health and Medical Research Council, Department of Health, Housing, Local Government and community Services, 1995.