Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.
Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.
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DOI：
10.1016/j.bmcl.2004.06.074
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发表时间：
2004-09
影响因子：
2.7
通讯作者：
T. Kam;K. Sim;Huey-Shen Pang;T. Koyano;M. Hayashi;K. Komiyama
中科院分区：
文献类型：
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作者：
T. Kam;K. Sim;Huey-Shen Pang;T. Koyano;M. Hayashi;K. Komiyama
评价了一系列伊波甘型吲哚生物碱的细胞毒性作用及其逆转长春新碱耐药KB细胞MDR的潜力。在测试的总共25种化合物中，发现3（S）-氰基冠孢定、3（S）-氰基异乌冈碱、3（S）-氰基乌冈碱和10，11-去甲氧基奇平碱对KB细胞显示出明显的细胞毒性，而发现冠孢定、黑宁碱、19-表-黑宁碱、地平碱B和地平碱C逆转长春新碱抗性KB细胞中的MDR。
A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.