Calcium and ROS: A mutual interplay.
Calcium and ROS: A mutual interplay.
复制标题
钙和ROS：相互互动。
DOI：
10.1016/j.redox.2015.08.010
复制
发表时间：
2015-12
期刊：
影响因子：
11.4
通讯作者：
Krizanova O
中科院分区：
文献类型：
--
作者：
Görlach A;Bertram K;Hudecova S;Krizanova O
钙离子是一种重要的第二信使，参与细胞内和细胞外的信号级联，并在细胞的生命和死亡决定中起着至关重要的作用。Ca2+信号网络以许多不同的方式工作，以调节由于缓冲液、泵和交换剂对质膜以及内部储存的作用而在宽动态范围内起作用的细胞过程。钙信号通路与其他细胞信号系统如活性氧（ROS）相互作用。虽然最初被认为是有氧代谢的潜在有害副产物，但现在清楚的是，不同细胞内系统以亚毒性水平产生的ROS充当参与各种细胞过程（包括生长和细胞死亡）的信号分子。越来越多的证据表明，钙和ROS信号系统之间的相互作用，这似乎有重要的意义微调细胞信号网络。然而，任何一个系统的功能障碍都可能影响另一个系统，从而增强有害影响，这可能导致各种疾病的发病机制。钙和ROS作为细胞内的信号分子，它们的通路可以相互作用。钙和ROS的相互作用是信号转导微调所必需的。相互作用的失败导致功能障碍和病理学。
Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca2+ signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders. Calcium and ROS act as signaling molecules inside the cell and their pathways can interact. The mutual interplay of calcium and ROS is required for the fine tuning of signaling. Failure in the interplay results in dysfunction and pathologies.