Cooperation, virulence and siderophore production in bacterial parasites
Cooperation, virulence and siderophore production in bacterial parasites
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DOI：
10.1098/rspb.2002.2209
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发表时间：
2003-01-07
影响因子：
4.7
通讯作者：
Buckling, A
中科院分区：
文献类型：
--
作者：
West, SA;Buckling, A
亲缘选择理论预测，寄生虫感染对宿主造成的损害（寄生虫毒力）将与宿主内寄生虫之间的亲缘关系负相关。这是因为较低的亲缘关系导致对宿主资源的更大竞争，这有利于快速生长以在宿主内获得更大的相对成功，而较高的寄生虫生长速度导致较高的毒力。我们表明，细菌感染的生物学特征可以导致相反的预测：亲缘关系和毒力之间的正相关。这是因为高亲缘关系有利于更多（合作）产生清除铁的分子（铁载体），从而导致更高的生长速度和毒性。更一般地说，同样的基本思想可以预测在任何情况下，在寄生虫可以合作提高其生长速度的情况下，亲缘性和毒性之间存在正相关关系；其他例子包括免疫抑制和帮助定植的生物膜的产生。
Kin selection theory predicts that the damage to a host resulting from parasite infection (parasite virulence) will be negatively correlated to the relatedness between parasites within the host. This occurs because a lower relatedness leads to greater competition for host resources, which favours rapid growth to achieve greater relative success within the host, and that higher parasite growth rate leads to higher virulence. We show that a biological feature of bacterial infections can lead to the opposite prediction: a positive correlation between relatedness and virulence. This occurs because a high relatedness can favour greater (cooperative) production of molecules that scavenge iron (siderophores), which results in higher growth rates and virulence. More generally, the same underlying idea can predict a positive relationship between relatedness and virulence in any case where parasites can cooperate to increase their growth rate; other examples include immune suppression and the production of biofilms to aid colonization.