The spinal terminations of single, physiologically characterized axons originating in the pontomedullary raphe of the cat.
The spinal terminations of single, physiologically characterized axons originating in the pontomedullary raphe of the cat.
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起源于猫的桥脑中缝的单个生理特征轴突的脊髓末端。
DOI：
10.1002/cne.902340410
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Light,AR
中科院分区：
文献类型：
--
作者：
Light,AR
在猫的背外侧索中记录了单髓鞘轴突，其生理特征为从中线髓质或中线脑桥下降。在进一步的生理特征（例如，传导速度、足够的刺激、感受野、刺激导水管周围灰质激活）之后，用辣根过氧化物酶标记轴突，并从记录微移液管中通过离子电渗疗法喷射。组织化学反应使染色的轴突及其在脊髓灰质中的树枝化得以可视化。采样轴突的传导速度范围为 7.3 至 117.2 m/秒，平均值为 35.5 m/秒。然而，使用此处采用的技术无法对无髓鞘轴突进行采样。下降轴突可分为两组：（1）终止于层板 I、II、V 和 X 的轴突，以及（2）终止于层板 V、VII 和 X 的轴突。两组轴突均具有有髓鞘的亲本轴突，被导水管周围灰色刺激激活，并对感受野的有害挤压做出反应。两组轴突的末端侧枝通常横向定向。这些结果表明这些下降轴突的异质功能可能包括调节伤害性输入到更高的中心。
Single myelinated axons were recorded in the dorsolateral funiculus of the cat and physiologically characterized as descending from the midline medulla or midline pons. Following further physiological characterization (e.g., conduction velocity, adequate stimulus, receptive field, activation by stimulation of periaqueductal gray), the axons were Labeled with horseradish peroxidase that was iontophoretically ejected from the recording micro‐pipette. Histochemical reaction allowed visualization of the stained axons and their arborizations in the spinal gray matter. The conduction velocities of the sampled axons ranged from 7.3 to 117.2 m/second with a mean of 35.5 m/second. However, unmyelinated axons could not be sampled with the technique employed here. Descending axons could be divided into two groups: (1) those which terminated in laminae I, II, V, and X, and (2) those which terminated in laminae V, VII, and X. Axons from both groups had myelinated parent axons, were activated by periaqueductal gray stimulation, and responded to noxious pinch of their receptive field Terminal collaterals from both groups of axons were generally transversely oriented. These results suggest heterogeneous functions for these descending axons which may include modulation of nociceptive input to higher centers.