A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease.
A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease.
复制标题
闭塞性细支气管炎与机化性肺炎、普通间质性肺炎和小气道疾病的比较。
DOI：
10.1164/arrd.1987.135.3.705
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
J. Hogg
中科院分区：
文献类型：
--
作者：
M. L. Guerry;N. Müller;J. Wright;B. Wiggs;C. Coppin;P. Paré;J. Hogg
本报告基于 43 例病例，通过肺活检诊断为闭塞性细支气管炎伴机化性肺炎 (BOOP)、普通间质性肺炎 (UIP) 或小气道疾病 (SAD)。使用半定量技术测量这些活检中外周气道和间质空间组织学异常的严重程度，并与 43 例中的 42 例的临床数据、43 例中的 31 例的术前胸片以及 43 例中的 29 例的术前肺功能测试进行比较。数据显示，当诊断 BOOP 时，膜性细支气管炎 (MB) 和呼吸性细支气管炎的总病理评分较高(RB) 高于 UIP 和 SAD（p 小于 0.005）。这是由于细支气管周围炎症和 RB 管腔中存在疏松结缔组织。 SAD 中的间质病理变化比 BOOP 或 UIP 中的要轻（p 小于 0.005）。 UIP 中杵状指更频繁（p 小于 0.01），而 BOOP 中症状持续时间更短（p 小于 0.05）。放射照相评估显示，BOOP 的特征性发现是斑片状空域实变，而 UIP 或 SAD 中不存在这一发现。
This report is based on 43 cases where a diagnosis of either bronchiolitis obliterans with organizing pneumonia (BOOP), usual interstitial pneumonia (UIP), or small airways disease (SAD) was established by lung biopsy. The severity of histologic abnormalities in the peripheral airways and interstitial spaces were measured on these biopsies using semiquantitative techniques and compared with the clinical data available in 42 of 43 cases, preoperative chest radiographs in 31 of 43, and preoperative pulmonary function tests in 29 of 43. The data show that when a diagnosis of BOOP was made, there was a higher total pathologic score for membraneous bronchiolitis (MB) and respiratory bronchiolitis (RB) than for UIP and SAD (p less than 0.005). This was due to peribronchiolar inflammation and the presence of loose connective tissue in the RB lumen. The pathologic changes in the interstitial space were less severe in SAD than in BOOP or UIP (p less than 0.005). Clubbing was more frequent in UIP (p less than 0.01), and symptoms were of shorter duration in BOOP (p less than 0.05). The radiographic assessment showed that the characteristic finding in BOOP was patchy air-space consolidation, a finding that was not present in UIP or SAD.