MOTIVATIONAL SENSORIMOTOR INTERACTION CONTROLS APHAGIA AND EXAGGERATED TREADING AFTER STRIATOPALLIDAL LESIONS
MOTIVATIONAL SENSORIMOTOR INTERACTION CONTROLS APHAGIA AND EXAGGERATED TREADING AFTER STRIATOPALLIDAL LESIONS
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DOI：
10.1037/0735-7044.104.5.778
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发表时间：
1990-10-01
影响因子：
1.9
通讯作者：
CROMWELL, HC
中科院分区：
文献类型：
--
作者：
BERRIDGE, KC;CROMWELL, HC
本研究探讨了纹状体感觉运动和动机功能之间的关系。在大鼠中，由红藻氨酸或使君子酸引起的纹状体（新纹状体和苍白球）的兴奋性毒性损伤可产生厌恶性吞咽障碍和“舞蹈病”感觉运动综合征：由口腔感觉刺激引发的前爪过度踩踏。实验1采用功能恢复的方法，表明（a）腹后纹状体苍白球损伤引起的吞咽障碍伴随着厌恶感的增强（B）食欲不振和强烈的厌恶感同时恢复;（c）夸张踩踏并没有随着无食欲厌恶而消失，而是将其诱发触发的范围缩小到了酸和苦的刺激。实验2使用了部分损伤的方法，以表明这种分离的增强厌恶和夸张的踩踏可以重现较小的病变后，立即striatopallidal损伤。实验3使用条件厌恶程序，以表明刺激夸张踩踏是厌恶（自然或条件），而不是一个简单的感官功能的口腔刺激。我们得出了三个结论：（a）在一个小的损伤后或在一个较大的损伤后部分恢复后的夸张踩踏，是由于嵌套在厌恶反应系统中的感觉运动关系的重组造成的;（B）夸张踩踏只由引起自然或条件性厌恶的味道引起;（c）更广泛的损伤增强了对正常可口的味道的厌恶，并扩大了踩踏诱发物的范围，包括这些味道。换句话说，情感系统和感觉运动系统在产生舞蹈踩踏中以分层的方式相互作用。这些结果表明，一个特定的层次之间的联系，由纹状体电路介导的动机和感觉运动功能。
This study examined the relationship between sensorimotor and motivational functions of the corpus striatum. In rats, excitotoxic lesions of the corpus striatum (neostriatum and globus pallidus) caused by kainic or quisqualic acid can produce both aversive aphagia and a “choreic” sensorimotor syndrome: an exaggerated treading of the forepaws that is triggered by oral sensory stimulation. Experiment 1 used a recovery-of-function approach to show that (a) aphagia induced by ventroposterior striatopallidal lesions was accompanied by an enhancement of aversion (a specific motivational process) to sweet stimuli, which was expressed in taste reactivity measures of affective evaluation;(b) aphagia and enhanced aversion recovered together; and (c) exaggerated treading did not disappear with aphagia–aversion but narrowed the range of its eliciting trigger to sour and bitter stimuli. Experiment 2 used a partial lesion approach to show that this dissociation of enhanced aversion and exaggerated treading could be reproduced by smaller lesions immediately after striatopallidal damage. Experiment 3 used a conditioned aversion procedure to show that the stimulus for exaggerated treading was aversion (natural or conditioned) and not a simple sensory feature of oral stimulation. Three conclusions were made:(a) Exaggerated treading after a small lesion or after partial recovery from a larger one results from a restructuring of a sensorimotor relations that is nested within a system of aversive reaction,(b) exaggerated treading is elicited only by tastes that elicit natural or conditioned aversion, and (c) more extensive lesions potentiate aversion to tastes that are normally palatable and expand the range of treading elicitors to include those tastes. In other words, affective and sensorimotor systems interact in a hierarchical manner in the production of choreic treading. These results demonstrate a specific hierarchical link between motivational and sensorimotor functions mediated by striatopallidal circuits.