Effects of short-term hypoxia on platelet counts of mice
Effects of short-term hypoxia on platelet counts of mice
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DOI：
10.1182/blood.v51.1.165.bloodjournal511165
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发表时间：
1978
期刊：
影响因子：
20.3
通讯作者：
T. McDonald;M. Cottrell;R. Clift
中科院分区：
文献类型：
--
作者：
T. McDonald;M. Cottrell;R. Clift
最近的研究表明，长期缺氧导致小鼠血小板计数下降，短期缺氧导致血小板计数增加。为了解释短期低氧暴露后小鼠血小板计数增加的机制，我们测量了血小板计数、总循环血小板计数（TCPC）、总循环血小板质量（TCPM）、35 S掺入百分比和血小板大小。缺氧1-3天后，小鼠血小板计数、TCPC和TCPM均升高，但6-7天后，这些值均降低。尽管缺氧小鼠的血小板计数增加，但35 S掺入血小板的百分比和血小板大小并未同时增加。缺氧6天后，平均血小板直径开始增加，血小板计数下降。脾脏释放不能解释短期缺氧后小鼠血小板计数的增加。因此，巨核细胞在缺氧时将血小板“脱落”到循环中似乎是可能的。响应于短期缺氧而进入循环的血小板比响应于急性血小板减少症而产生的血小板更小并且结合更少的35 S。
Recent studies have shown that long-term hypoxia causes decreased platelet counts in mice and short-term hypoxia increased platelet counts. In an attempt to explain the mechanism that increases platelet counts of mice after exposure to short-term hypoxia, we measured platelet counts, total circulating platelet counts (TCPC), total circulating platelet masses (TCPM), percentages of 35S incorporation, and platelet sizes. Platelet counts, as well as TCPC and TCPM of mice, increased after 1-3 days of hypoxia, but these values were decreased after 6-7 days of hypoxia. Although platelet counts were increased in hypoxic mice, the percentage 35S incorporation into platelets and platelet sizes did not show a concurrent increase. After 6 days of hypoxia, average platelet diameters began to increase as platelet counts decreased. Splenic release did not account for the increase in platelet counts of mice after short-term hypoxia. It seems possible, therefore, that megakaryocytes "shed" platelets into the circulation in response to hypoxia. The platelets that enter the circulation in response to short-term hypoxia are smaller and incorporate less 35S than platelets that are produced in response to acute thrombocytopenia.